Preliminary test used to diagnose thyroid disorders. TSH is generally high in primary hypothyroidism and low TSH occurs in hyperthyroidism. Evaluation of hormone replacement therapy in hypothyroid patients receiving various thyroid hormone preparations: Low values are found in states of excessive thyroid replacement. Normal result on a sensitive TSH assay is acceptable evidence of adequate thyroid replacement. High values are found in cases where a higher dosage of thyroid replacement is needed. The third-generation TSH assay can be considered a test for thyroid disease. A result within the accepted reference interval provides strong evidence for euthyroidism. Also, TSH is not elevated in secondary hypothyroidism.
Please visit our CLINICAL EDUCATION CENTER to stay informed on any future publications, webinars, or other education opportunities.
Thyroid-stimulating Hormone (TSH)
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
|0 to 6 d||0.700−15.200|
|7 d to 3 m||0.720−11.000|
|3 m 1 d to 12 m||0.730−8.350|
|1 to 5 y||0.700−5.970|
|6 to 10 y||0.600−4.840|
Third-generation TSH, Thyrotropin
Red-top tube or gel-barrier tube
0.3 mL (Note: This volume does not allow for repeat testing.)
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Red-top tube, SST, Serum Aliquot
Room temperature 14 days Refrigerated 14 days Frozen 14 days Freeze/thaw cycles Stable x3
Citrate plasma specimen; improper labeling